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Acute Ischemic Stroke and COVID-19: Analysis of 27,676 Patients
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Using data from the Cerner de-identified COVID-19 dataset and from 54 facilities and 103 patients with COVID-19–associated stroke, the authors found that the proportion of patients with hypertension, diabetes, hyperlipidemia, atrial fibrillation, and congestive heart failure was significantly higher among those with acute ischemic stroke compared with non-stroke COVID-19–positive patients. Among 8163 patients with COVID-19, 1.3% developed acute ischemic stroke. The authors concluded that acute ischemic stroke was infrequent in patients with COVID-19 and usually occurred in the presence of other cardiovascular risk factors.
- Although these observations are not surprising, this is a valuable descriptive analysis of data from a large cohort of patients during the current pandemic, identifying the incidence of stroke and the risk factors associated with it.
abstract
This abstract is available on the publisher's site.
Access this abstract nowBACKGROUND AND PURPOSE
Acute ischemic stroke may occur in patients with coronavirus disease 2019 (COVID-19), but risk factors, in-hospital events, and outcomes are not well studied in large cohorts. We identified risk factors, comorbidities, and outcomes in patients with COVID-19 with or without acute ischemic stroke and compared with patients without COVID-19 and acute ischemic stroke.
METHODS
We analyzed the data from 54 health care facilities using the Cerner deidentified COVID-19 dataset. The dataset included patients with an emergency department or inpatient encounter with discharge diagnoses codes that could be associated to suspicion of or exposure to COVID-19 or confirmed COVID-19.
RESULTS
A total of 103 (1.3%) patients developed acute ischemic stroke among 8163 patients with COVID-19. Among all patients with COVID-19, the proportion of patients with hypertension, diabetes, hyperlipidemia, atrial fibrillation, and congestive heart failure was significantly higher among those with acute ischemic stroke. Acute ischemic stroke was associated with discharge to destination other than home or death (relative risk, 2.1 [95% CI, 1.6-2.4]; P<0.0001) after adjusting for potential confounders. A total of 199 (1.0%) patients developed acute ischemic stroke among 19 513 patients without COVID-19. Among all ischemic stroke patients, COVID-19 was associated with discharge to destination other than home or death (relative risk, 1.2 [95% CI, 1.0-1.3]; P=0.03) after adjusting for potential confounders.
CONCLUSIONS
Acute ischemic stroke was infrequent in patients with COVID-19 and usually occurs in the presence of other cardiovascular risk factors. The risk of discharge to destination other than home or death increased 2-fold with occurrence of acute ischemic stroke in patients with COVID-19.
Additional Info
Disclosure statements are available on the authors' profiles:
Acute Ischemic Stroke and COVID-19: An Analysis of 27 676 Patients
Stroke 2021 Mar 01;52(3)905-912, AI Qureshi, WI Baskett, W Huang, D Shyu, D Myers, M Raju, I Lobanova, MFK Suri, SH Naqvi, BR French, F Siddiq, CR Gomez, CR ShyuFrom MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.