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The authors of this retrospective analysis evaluated coagulation parameters in 183 patients admitted with the severe novel coronavirus COVID-19. Median age at admission was 54 years, and 71.4% of non-survivors developed overt disseminated intravascular coagulation (DIC), with a median time from admission to DIC of 4 days. Only 0.6% of survivors developed DIC. On admission, non-surviving patients presented with higher D-dimer levels, prolonged PT, and aPTT compared with surviving patients.
In patients with COVID-19 infection, the development of coagulopathy and overt DIC appears to be associated with a high mortality rate. Larger analyses confirming these findings and investigating both the pathophysiology and impact of correction of coagulopathy on mortality are warranted.
– Curtis Lachowiez, MD
This abstract is available on the publisher's site.
In the recent outbreak of novel coronavirus infection in Wuhan, China, significantly abnormal coagulation parameters in severe novel coronavirus pneumonia (NCP) cases were a concern.
To describe the coagulation feature of patients with NCP.
Conventional coagulation results and outcomes of consecutive 183 patients with confirmed NCP in Tongji hospital were retrospectively analysed.
The overall mortality was 11.5%, the non-survivors revealed significantly higher D-dimer and fibrin degradation product (FDP) levels, longer prothrombin time and activated partial thromboplastin time compared to survivors on admission (P<0.05). 71.4% of non-survivors and 0.6% survivors met the criteria of disseminated intravascular coagulation during their hospital stay.
The present study shows that abnormal coagulation results, especially markedly elevated D-dimer and FDP are common in deaths with NCP.