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Expert Opinion / Cases · March 16, 2022

65-Year-Old Postmenopausal Woman With Recurrent Metastatic ER+ PR– HER2– Lobular Breast Cancer

Written by
Ana C. Sandoval Leon MD


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  • Jose A Garcia-Saenz

    Mar 18, 2022

    Consider a Clinical Trial otherwise Alpelisib, either with FUL or NSAI as ET backbone


    Mar 18, 2022


  • Sandro Barni

    Mar 18, 2022

    Continue Fulvestrant and change Abemaciclib to Alpelisib

  • satadru ray

    Mar 18, 2022

    Fulvestrant with alpelisib

  • nadire kucukoztas

    Mar 18, 2022

    Since the patient is hormone resistant, I recommend capecitabine treatment to the patient. 

  • luis betancourt

    Mar 18, 2022

    test BRCA

  • Feng-Jen Chen

    Mar 18, 2022

    Continue Fulvestrant and change Abemaciclib to Alpelisib

  • mindy bohrer

    Mar 18, 2022

    fulvestrant plus alpelisib

  • hamid rezvani

    Mar 18, 2022

    continue fulvestrant and replace abemaciclib for alpelisib

  • pramod kumar julka

    Mar 19, 2022

    Alpelisib with fulvestrant 

  • Claus Schlotter

    Mar 19, 2022

    nab-Paclitaxel weekly

  • Luca Licata

    Mar 19, 2022

    The patient had a disease progression 6 months after starting the 1st line endocrine-based therapy (i.e. primary endocrine resistance) and her best response to the 2nd line endocrine-based therapy was a stable disease. I’m not sure that another endocrine-based therapy might be her best option. I would opt for paclitaxel (an oral therapy like capecitabine it’s not the best option in the case of peritoneal metastases and the possible risk of bowel obstruction) 

  • Bogdan Cristian Dinu

    Mar 21, 2022

    biopsy if it is not so harmfull from peritoneum end adapt treatment afterthat , usually the bone mets are different biology from visceral secondary lesions.

  • Sep 28, 2023

    Pending Moderator approval.

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