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Expert Opinion / Commentary · December 08, 2022

2022 Top Story in Brain Cancer: Proton Craniospinal Irradiation for Leptomeningeal Disease

Written by
Rupesh R. Kotecha MD


Additional Info

  1. Lamba N, Wen PY, Aizer AA. Epidemiology of Brain Metastases and Leptomeningeal Disease. Neuro Oncol. 2021;23(9):1447-1456.
  2. Palmisciano P, Watanabe G, Conching A, et al. Intrathecal therapy for the management of leptomeningeal metastatic disease: a scoping review of the current literature and ongoing clinical trials. J Neurooncol. 2022;160(1):79-100.
  3. Le Rhun E, Ruda R, Devos P, et al. Diagnosis and treatment patterns for patients with leptomeningeal metastasis from solid tumors across Europe. J Neurooncol. 2017;133(2):419-427.
  4. Harada H, Mitsuya K, Asakura H, et al. Cranio-Spinal Irradiation for Leptomeningeal Carcinomatosis: A Pilot Study. Int J Radiat Oncol Biol Phys. 2014;90(1):S310.
  5. Devecka M, Duma MN, Wilkens JJ, et al. Craniospinal irradiation(CSI) in patients with leptomeningeal metastases: risk-benefit-profile and development of a prognostic score for decision making in the palliative setting. BMC Cancer. 2020;20(1):501.
  6. Le Rhun E, Weller M, Brandsma D, et al. EANO-ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with leptomeningeal metastasis from solid tumours. Ann Oncol. 2017;28(suppl_4):iv84-iv99.
  7. Brown AP, Barney CL, Grosshans DR, et al. Proton beam craniospinal irradiation reduces acute toxicity for adults with medulloblastoma. Int J Radiat Oncol Biol Phys. 2013;86(2):277-284.
  8. Yang TJ, Wijetunga NA, Yamada J, et al. Clinical trial of proton craniospinal irradiation for leptomeningeal metastases. Neuro Oncol. 2021;23(1):134-143.
  9. Yang JT, Wijetunga NA, Pentsova E, et al. Randomized Phase II Trial of Proton Craniospinal Irradiation Versus Photon Involved-Field Radiotherapy for Patients With Solid Tumor Leptomeningeal Metastasis. J Clin Oncol. 2022 Jul 8. Doi: 10.1200/JCO.22.01148. Online ahead of print.

Disclosure statements are available on the authors' profiles:

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