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Published in Benign Hematology

Expert Opinion / Commentary · December 09, 2022

2022 Top Story in Benign Hematology: Tranexamic Acid

Written by
Michael H. Kroll MD


Additional Info

  1. Mannucci PM. Hemostatic drugs. N Engl J Med. 1998;339(4):245-253.
  2. Franchini M, Mannucci PM. The never ending success story of tranexamic acid in acquired bleeding. Haematologica. 2020;105(5):1201-1205.
  3. Ross J, Al-Shahi Salman R. The frequency of thrombotic events among adults given antifibrinolytic drugs for spontaneous bleeding: systematic review and meta-analysis of observational studies and randomized trials. Curr Drug Saf. 2012;7(1):44-54.
  4. Relke N, Chornenki NLJ, Sholzberg M. Tranexamic acid evidence and controversies: An illustrated review. Res Pract Thromb Haemost. 2021;5(5):e12546.
  5. CRASH-3 trial collaborators. Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial. Lancet. 2019;394(10210):1713-1723.
  6. Sprigg N, Flaherty K, Appleton JP, et al. Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial. Lancet. 2018;391(10135):2107-2115.
  7. Pszczolkowski S, Sprigg N, Woodhouse LJ, et al. Effect of Tranexamic Acid Administration on Remote Cerebral Ischemic Lesions in Acute Spontaneous Intracerebral Hemorrhage: A Substudy of a Randomized Clinical Trial. JAMA Neurol. 2022;79(5):468-477.
  8. Tjerkstra MA, Post R, Germans MR, et al. Tranexamic Acid After Aneurysmal Subarachnoid Hemorrhage: Post-Hoc Analysis of the ULTRA Trial. Neurology. 2022 Oct 20. doi: 10.1212/WNL.0000000000201160. Online ahead of print.
  9. Estcourt LJ, Desborough M, Brunskill SJ, et al. Antifibrinolytics (lysine analogues) for the prevention of bleeding in people with haematological disorders. Cochrane Database Syst Rev. 2016;3(3):CD009733.
  10. Gernsheimer TB, Brown SP, Triulzi DJ, et al. Prophylactic tranexamic acid in patients with hematologic malignancy: a placebo-controlled, randomized clinical trial. Blood. 2022;140(11):1254-1262.
  11. Antun AG, Gleason S, Arellano M, et al. Epsilon aminocaproic acid prevents bleeding in severely thrombocytopenic patients with hematological malignancies. Cancer. 2013;119(21):3784-3787.
  12. Yang W, Tholpady A, Casteel KN, et al. Platelet-refractoriness and the clinical impact in leukemia population at a metropolitan academic cancer center. Leuk Lymphoma. 2020;61(4):996-998.
  13. Devereaux PJ, Marcucci M, Painter TW, et al. Tranexamic Acid in Patients Undergoing Noncardiac Surgery. N Engl J Med. 2022;386(21):1986-1997.
  14. Fowler H, Law J, Tham SM, et al. Impact on blood loss and transfusion rates following administration of tranexamic acid in major oncological abdominal and pelvic surgery: A systematic review and meta-analysis. J Surg Oncol. 2022;126(3):609-621.
  15. Smilowitz NR, Oberweis BS, Nukala S, et al. Association Between Anemia, Bleeding, and Transfusion with Long-term Mortality Following Noncardiac Surgery. Am J Med. 2016;129(3):315-23.e2.

Disclosure statements are available on the authors' profiles:

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