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Published in Respiratory Medicine

Expert Opinion / Commentary · December 10, 2020

2020 Top Stories in Respiratory Medicine: The CAPTAIN and IRIDIUM Trials

Written by
Geoffrey R. Connors MD, FACP

 

Additional Info

  1. Singh D, Papi A, Corradi M, et al. Single inhaler triple therapy versus inhaled corticosteroid plus long-acting β2-agonist therapy for chronic obstructive pulmonary disease (TRILOGY). Lancet. 2016;388(10048):963-973.
  2. Lipson DA, Barnhart F, Brealey N, et al. Once-daily single-inhaler triple versus dual therapy in patients with COPD. N Engl J Med. 2018;378(18):1671-1680.
  3. Papi A, Vestbo J, Fabbri L, et al. Extra fine inhaled triple therapy versus dual bronchodilator therapy in chronic obstructive pulmonary disease (TRIBUTE): a double-blind, parallel group, randomised controlled trial. Lancet. 2018;391(10125):1076-1084.
  4. Kerstjens HA, Disse B, Schröder-Babo W, et al. Tiotropium improves lung function in patients with severe uncontrolled asthma: a randomized controlled trial. J Allergy Clin Immunol. 2011;128(2):308.
  5. Kerstjens HA, Engel M, Dahl R, et al. Tiotropium in asthma poorly controlled with standard combination therapy. N Engl J Med. 2012;367(13):1198-1207.
  6. Virchow JC, Kuna P, Paggiaro P, et al. Single inhaler extrafine triple therapy in uncontrolled asthma (TRIMARAN and TRIGGER): two double-blind, parallel-group, randomised, controlled phase 3 trials. Lancet. 2019; 394(10210):1737-1749.
  7. Lee LA, Bailes Z, Barnes N, et al. Efficacy and safety of once-daily singleinhaler triple therapy (FF/UMEC/VI) versus FF/VI in patients with inadequately controlled asthma (CAPTAIN): a double-blind, randomised, phase 3A trial. Lancet Respir Med. 2020 Sep 9. doi: 10.1016/S2213-2600(20)30389-1. Online ahead of print.
  8. Kerstjens HAM, Maspero J, Chapman KR, et al; IRIDIUM Trial Investigators. Once-daily, single-inhaler mometasone-indacaterol-glycopyrronium versus mometasone-indacaterol or twice-daily fluticasone-salmeterol in patients with inadequately controlled asthma (IRIDIUM): a randomised, double-blind, controlled phase 3 study. Lancet Respir Med. 2020;8(10):1000-1012.

Disclosure statements are available on the authors' profiles:

Further Reading