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Published in Respiratory Medicine

Expert Opinion / Commentary · December 10, 2020

2020 Top Stories in Respiratory Medicine: The CAPTAIN and IRIDIUM Trials

Written by
Geoffrey R. Connors MD, FACP

 

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Additional Info

  1. Singh D, Papi A, Corradi M, et al. Single inhaler triple therapy versus inhaled corticosteroid plus long-acting β2-agonist therapy for chronic obstructive pulmonary disease (TRILOGY). Lancet. 2016;388(10048):963-973.
  2. Lipson DA, Barnhart F, Brealey N, et al. Once-daily single-inhaler triple versus dual therapy in patients with COPD. N Engl J Med. 2018;378(18):1671-1680.
  3. Papi A, Vestbo J, Fabbri L, et al. Extra fine inhaled triple therapy versus dual bronchodilator therapy in chronic obstructive pulmonary disease (TRIBUTE): a double-blind, parallel group, randomised controlled trial. Lancet. 2018;391(10125):1076-1084.
  4. Kerstjens HA, Disse B, Schröder-Babo W, et al. Tiotropium improves lung function in patients with severe uncontrolled asthma: a randomized controlled trial. J Allergy Clin Immunol. 2011;128(2):308.
  5. Kerstjens HA, Engel M, Dahl R, et al. Tiotropium in asthma poorly controlled with standard combination therapy. N Engl J Med. 2012;367(13):1198-1207.
  6. Virchow JC, Kuna P, Paggiaro P, et al. Single inhaler extrafine triple therapy in uncontrolled asthma (TRIMARAN and TRIGGER): two double-blind, parallel-group, randomised, controlled phase 3 trials. Lancet. 2019; 394(10210):1737-1749.
  7. Lee LA, Bailes Z, Barnes N, et al. Efficacy and safety of once-daily singleinhaler triple therapy (FF/UMEC/VI) versus FF/VI in patients with inadequately controlled asthma (CAPTAIN): a double-blind, randomised, phase 3A trial. Lancet Respir Med. 2020 Sep 9. doi: 10.1016/S2213-2600(20)30389-1. Online ahead of print.
  8. Kerstjens HAM, Maspero J, Chapman KR, et al; IRIDIUM Trial Investigators. Once-daily, single-inhaler mometasone-indacaterol-glycopyrronium versus mometasone-indacaterol or twice-daily fluticasone-salmeterol in patients with inadequately controlled asthma (IRIDIUM): a randomised, double-blind, controlled phase 3 study. Lancet Respir Med. 2020;8(10):1000-1012.

Disclosure statements are available on the authors' profiles:

Geoffrey Connors MD, FACP

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