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Published in Clinical Dentistry

Expert Opinion / Commentary · December 05, 2020

2020 Top Stories in Clinical Dentistry: Immune System Imbalance Is Behind Marginal Bone Loss Around Oral Implants

Written by
George A. Kotsakis DDS, MS


Additional Info

  1. Albrektsson T, Dahlin C, Reinedahl D, et al. An imbalance of the immune system instead of a disease behind marginal bone loss around oral implants: Position paper. Int J Oral Maxillofac Implants. 2020;35(3):495-502.
  2. Albrektsson T, Dahlin C, Reinedahl D, et al. Immune System Imbalance — Not a Disease — Behind Marginal Bone Loss Around Oral Implants. PracticeUpdate website. Accessed November 10, 2020.
  3. Daubert DM, Weinstein BF. Biofilm as a risk factor in implant treatment. Periodontol 2000. 2019;81(1):29-40.
  4. Kotsakis GA. Minimizing risk of bias in clinical implant research study design. Periodontol 2000. 2019;81(1):18-28.
  5. Donath K, Laass M, Gunzl HJ. The histopathology of different foreign-body reactions in oral soft tissue and bone tissue. Virchows Arch A Pathol Anat Histopathol. 1992;420(2):131-137.
  6. Koutouzis T, Catania D, Neiva K, Wallet SM. Innate immune receptor expression in peri-implant tissues of patients with different susceptibility to periodontal diseases. J Periodontol. 2013;84(2):221-229.
  7. Albrektsson T, Gottlow J, Meirelles L, et al. Survival of nobeldirect implants: an analysis of 550 consecutively placed implants at 18 different clinical centers. Clin Implant Dent Relat Res. 2007;9(2):65-70.
  8. Siddiqui DA, Guida L, Sridhar S, et al . Evaluation of oral microbial corrosion on the surface degradation of dental implant materials. J Periodontol. 2019;90(1):72-81.
  9. Delgado-Ruiz R, Romanos G. Potential causes of titanium particle and ion release in implant dentistry: a systematic review. Int J Mol Sci. 2018;19(11):3585.
  10. Eger M, Sterer N, Liron T, et al. Scaling of titanium implants entrains inflammation-induced osteolysis. Sci Rep. 2017;7:39612.
  11. Kotsakis GA, Black R, Kum J, et al. Effect of implant cleaning on titanium particle dissolution and cytocompatibility. J Periodontol. 2020 AUG 26. doi:10.1002/JPER.20-0186. Online ahead of print.

Disclosure statements are available on the authors' profiles:

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