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Expert Opinion / Commentary · December 18, 2020

2020 Top Stories in Bladder Cancer: Switch-Maintenance Avelumab Following First-Line Platinum-Based Chemotherapy—A New Paradigm in Advanced Urothelial Carcinoma

Written by
Guru Sonpavde MD


Additional Info

  1. Powles T, Park SH, Voog E, et al. Avelumab maintenance therapy for advanced or metastatic urothelial carcinoma. N Engl J Med. 2020;383(13):1218-1230.
  2. Alva A, Csőszi T, Ozguroglu M, et al. Pembrolizumab (P) combined with chemotherapy (C) vs C alone as first-line (1L) therapy for advanced urothelial carcinoma (UC): KEYNOTE-361. Ann Oncol. 2020;31(suppl 4):LBA23.
  3. Powles T, van der Heijden MS, Castellano D, et al; DANUBE study investigators. Durvalumab alone and durvalumab plus tremelimumab versus chemotherapy in previously untreated patients with unresectable, locally advanced or metastatic urothelial carcinoma (DANUBE): a randomised, open-label, multicentre, phase 3 trial. Lancet Oncol. 2020 Sep 21. doi:10.1016/S1470-2045(20)30541-6. Online ahead of print.
  4. Opdivo (nivolumab) significantly improves disease free-survival vs. placebo as adjuvant therapy for patients with high-risk, muscle-invasive urothelial carcinoma in phase 3 CheckMate -274 trial. News release. September 24, 2020. Accessed November 20, 2020.
  5. Study of nivolumab in combination with ipilimumab or standard of care chemotherapy compared to the standard of care chemotherapy alone in treatment of participants with untreated inoperable or metastatic urothelial cancer (CheckMate901). ClinicalTrials.gov. Updated October 8, 2020. Accessed November 20, 2020.
  6. Enfortumab vedotin and pembrolizumab vs. chemotherapy alone in untreated locally advanced or metastatic urothelial cancer (EV-302). ClinicalTrials.gov. Updated November 16, 2020. Accessed November 20, 2020.

Further Reading