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Published in Benign Hematology

Expert Opinion / Commentary · December 03, 2020

2020 Top Stories in Benign Hematology: COVID-19–Associated Coagulopathy

Written by
Michael H. Kroll MD


Additional Info

  1. Varga Z, Flammer AJ, Steiger P, et al. Endothelial cell infection and endotheliitis in COVID-19. Lancet. 2020;395(10234):1417-1418.
  2. Al-Samkari H, Karp Leaf RS, Dzik WH, et al. COVID and coagulation: bleeding and thrombotic manifestations of SARS-CoV2 infection. Blood. 2020;136(4):489-500.
  3. Machlus KR, Cardenas JC, Church FC, Wolberg AS. Causal relationship between hyperfibrinogenemia, thrombosis, and resistance to thrombolysis in mice. Blood. 2011;117(18):4953-4963.
  4. Harr JN, Moore EE, Chin TL, et al. Postinjury hyperfibrinogenemia compromises efficacy of heparin-based VTE prophylaxis. Shock. 2014;41(1):33-39.
  5. Ackermann M, Verleden SE, Kuehnel M, at al. Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19. N Engl J Med. 2020;383(2):120-128.
  6. Hill JB, Garcia D, Crowther M, et al. Frequency of venous thromboembolism in 6513 patients with COVID-19: a retrospective study. Blood Adv. 2020;4(21):5373-5377.
  7. Patel R, Bogue T, Koshy A, et al. Post-discharge thrombosis and hemorrhage in patients with COVID-19. Blood. 2020;136(11):1342-1346.
  8. Yu J, Yuan X, Chen H, et al. Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition. Blood. 2020;136(18):2080-2089.
  9. Batinelli EM. COVID-19 concerns aggregate around platelets. Blood. 2020;136(11):1221-1223.
  10. Nadkarni GN, Lala A, Bagiella E, et al. Anticoagulation, bleeding, mortality and pathology in hospitalized patients with COVID-19. J Am Coll Cardiol. 2020;76(16):1815-1826.
  11. Choudry FA, Hamshere SM, Rathod KS, et al. High thrombus burden in patients with COVID-19 presenting with ST-segment elevation myocardial infarction. J Am Coll Cardiol. 2020;76(10):1168-1176.
  12. Oxley TJ, Mocco J, Majid S, et al. Large-vessel stroke as a presenting feature of COVID-19 in the young. N Engl J Med. 2020;382(20):e60.
  13. Bikdeli B, Madhavan MV, Jimenez D, et al. COVID-19 and thrombotic or thromboembolic disease: implications for prevention, antithrombotic therapy, and follow-up: JACC state-of-the-art review. J Am Coll Cardiol. 2020;75(23):2950-2973.
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  15. Hidalgo A. A NET-thrombosis axis in COVID-19. Blood. 2020;136(10):1118-1119.
  16. Radermecker C, Detrembleur N, Guiot J, et al. Neutrophil extracellular traps infiltrate the lung airway, interstitial, and vascular compartments in severe COVID-19. J Exp Med. 2020;217(12):e20201012.

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