Yannick Tholance MDMedical Biologist, Biochemistry Laboratory, Saint-Etienne University Hospital Centre, Saint-Etienne, France; Researcher, Synatac Laboratory (Synaptopathies and Autoantibodies), Neuromyogenic Institute, Lyon, France
Dr. Tholance is a medical biologist in the biochemistry laboratory of the Saint-Etienne University Hospital Centre and a researcher in the Synatac Laboratory (Synaptopathies and Autoantibodies) of the Neuromyogenic Institute (INMG). He and his research colleagues in Saint-Etienne work on the identification of new autoimmune biomarkers as autoantibodies in peripheral neuropathies and on the pathophysiological characterization of these biomarkers. By integrating basic and clinical research, they develop research tools to find new biomarkers and to confirm the interest of these biomarkers, describe the clinical characteristics of positive patients, and propose to study at the cellular and molecular levels the potential pathophysiological role of these autoantibodies in the development of the neuropathies. The objective of their research is to provide assistance to neurologists in the etiological diagnosis of peripheral neuropathies by transferring their methods of screening in the routine practice and to improve the care of these patients at the therapeutic level, using more fundamental knowledge on the pathophysiology of these peripheral neuropathies with autoimmune origin.