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Marc Pfeffer

Marc A Pfeffer MD, PhD

Dzau Professor of Medicine, Harvard Medical School, Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusettes

Dr. Marc Pfeffer is currently the Dzau Professor of Medicine at Harvard Medical School. He is Senior Physician in the Cardiovascular Division at the Brigham and Women’s Hospital in Boston, and Director of the Cardiovascular Grand Rounds Program. He also serves as Medical Director of Partners Research and Education Program.

A noted researcher, Dr. Pfeffer, along with his late wife, Dr. Janice Pfeffer, and Eugene Braunwald MD, is credited with introducing the concept that angiotensin-converting enzyme inhibitors (ACEIs) could attenuate ventricular remodelling following myocardial infarction and that this use would result in a prolongation of survival and other clinical benefits. Since this initial discovery, he has had a principal role in several practice-changing clinical trials such as SAVE, CARE, HEART, VALIANT, CHARM, PEACE, ARISE, TREAT, ALTITUDE and RED-HF. He is currently a leading investigator in TOPCAT and ELIXA. In addition to his role as researcher in the field of cardiovascular disease, coronary artery disease, heart failure, diabetes and chronic kidney disease, Dr. Pfeffer plays an active role in the academic development of trainees and junior faculty collaborating in trials. As the leader of Partners Research and Education Program (PREP), he has developed networks of community-based physicians who enjoy making meaningful contributions to clinical investigation.

Dr. Pfeffer is Senior Associate Editor of Circulation and is a member of the Editorial Board of several other prominent journals. He serves on the Data Safety Monitoring Boards of prominent international trials. 

An internationally recognized expert in the field of cardiology, he was, in 2006, recognized by Science Watch as having the most ‘Hot Papers’ (highly cited) in all of clinical medicine. He is the recipient of the William Harvey Award of the American Society of Hypertension, the Okamoto Award from Japan’s Vascular Disease Research Foundation and the Clinical Research Prize of the American Heart Association. Dr. Pfeffer is an Honorary Fellow of the Royal College of Physicians and Surgeons of Glasgow.