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Joost Smolders MD, PhD

Joost Smolders MD, PhD

Associate Professor and Consultant Neurologist, MS Center ErasMS, Departments of Neurology and Immunology, Erasmus MC, Rotterdam, The Netherlands; Visiting Researcher, Neuroimmunology Research Group, Netherlands Institute for Neuroscience, Royal Academy for Arts and Sciences, Amsterdam, The Netherlands

Joost Smolders is a neurologist and associate professor at the departments of Neurology and Immunology of Erasmus University Medical Center Rotterdam. He heads the MS center ErasMS and works as researcher at the Neuroimmunology research group of the Netherlands Institute for Neuroscience Amsterdam.

His research has a focus on understanding normal immune surveillance of the human brain by T cells, and the contribution of pathogenic B and T cells to neuroinflammatory disorders, such as multiple sclerosis (MS), neuromyelitis optica spectrum-disease, and MOG-associated disease. He studies cohorts of patients with these diseases using translational approaches, including genetics, immunology, and post-mortem pathology research.

His main scientific contributions are the investigation vitamin D supplements in an MS clinical trial, the identification and characterization of tissue-resident memory T cells in the post-mortem human brain, and the validation of an MS-progression single nucleotide polymorphism in post-mortem brain tissue. Furthermore, his research-lines aim on a more targeted and cost-effective application of diseases-modifying therapies in MS.

Besides his research, he works as consultant neurologist at the MS center ErasMS and the department of Neurology of Erasmus MC, and he serves in the board of the MS working group of the Dutch Society for Neurology. He is member of the European Academy for Neurology and the International Society for Neuroimmunology.


Joost Smolders has received lecture and/or consultancy fee from Biogen, Merck, Novartis, Roche, and Sanofi Genzyme.