Edward P. Manning MD, PhDSection of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut; VA Connecticut Healthcare System, West Haven, Connecticut
Ed is a native of Syracuse, NY. After earning undergraduate degree in physics, he was commissioned as a Marine Corps Officer. He served in the Marine Corps for ten years, pursued a graduate degree in physics then attended the Albert Einstein College of Medicine where he earned his MD and PhD degrees. His doctoral thesis resulted in the first dynamic, atomistic model of the cardiac thin filament that correlated experimental allosteric binding effects of calcium with molecular dynamic alterations observed in silico. This work provided insights into the fundamental molecular effects of mutations associated with familial hypertrophic cardiomyopathy. He has also published on dive medicine and the effects of oxygen therapy thanks to his professional experiences as a military diver and hyperbaric technician.
Ed attended residency at the Hospital of the University of Pennsylvania and completed a clinical and research fellowship in pulmonary and critical care medicine at Yale School of Medicine where he is currently an instructor of pulmonary and critical care medicine and a hospitalist and intensivist in the VA Connecticut Healthcare System in West Haven, CT. His current research focuses on the effects of hypoxia and aging on the pulmonary artery. He uses a multi-disciplinary approach ranging from transcriptomics to tissue biomechanics to investigate how changes in the pulmonary artery occur and potential interventions to mitigate maladaptive responses.