D. Brent Polk MDProfessor and Chair, Department of Pediatrics; Vice Dean for Child Health, Keck School of Medicine, University of Southern California, Los Angeles, California. Physician-in-Chief; Vice President for Academic Affairs; Director, Saban Research Institute, Children’s Hospital Los Angeles
D. Brent Polk, MD, is the Chair of the Department of Pediatrics and Vice-Dean for Child Health at the Keck School of Medicine of the University of Southern California. He is Physician-in-Chief, Vice-President for Academic Affairs, and Director of The Saban Research Institute of Children’s Hospital Los Angeles. He previously served as chief of Pediatric Gastroenterology, Hepatology and Nutrition, as well as director of the NIH funded Digestive Disease Research Center at Vanderbilt University and is a Fellow of the American Gastroenterology Association (AGAF).
His research is focused on the regulation of growth and development of the intestine as it relates to ontogeny and disease. Current areas of investigation include epidermal growth factor and tumor necrosis factor receptor family member signaling mechanisms leading to proliferation, differentiation, survival or migration of intestinal cells and the relationship between inflammation and tumorigenesis. These findings have been extended to understanding the relationship between commensal and pathogenic enteric bacterial flora and regulation of intestinal cell proliferation, integrity and apoptosis with implications for health and disease. He has mentored undergraduate, graduate and medical students, postdoctoral and clinical fellows as well as junior faculty. Dr. Polk is a member of several professional organizations, including the American Academy of Pediatrics, the AGA, the American Pediatric Society, the American Physiological Society, the American Society for the Biochemistry and Molecular Biology, the Society for Pediatric Research and serves on the Board of Directors of AMSPDC, Association of Medical School Pediatric Department Chairs. He is certified by the American Board of Pediatrics and the Subspecialty Boards in Gastroenterology.
Recent Contributions to PracticeUpdate:
- Efficacy of Fecal Microbiota Transplantation for Clostridium difficile Infection in Children
- Increased Mortality of Patients With Childhood-Onset IBD Compared With the General Population
- Mucosal Gene Expression Distinguishes Ulcerative Colitis From Colon-Only Crohn's Disease in Treatment-Naïve Pediatric Patients
- Increased Prevalence of Celiac Disease in Children With IBS