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Published in Oncology

Expert Opinion / Commentary · December 13, 2023

2023 Top Story in Oncology: PD-1 Inhibition for Nasopharyngeal Cancer

Written by
Barbara Burtness MD

 

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Additional Info

  1. Burtness B, Harrington K, Greil R, et al. Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study. Lancet. 2019;394:1915-1928.
  2. Ma BBY, Lim WT, Goh BC, et al. Antitumor Activity of Nivolumab in Recurrent and Metastatic Nasopharyngeal Carcinoma: An International, Multicenter Study of the Mayo Clinic Phase 2 Consortium (NCI-9742). J Clin Oncol. 2018;36(14):1412-1418.
  3. Chan ATC, Lee VHF, Hong RL, et al. Pembrolizumab monotherapy versus chemotherapy in platinum-pretreated, recurrent or metastatic nasopharyngeal cancer (KEYNOTE-122): an open-label, randomized, phase III trial. Ann Oncol. 2023;34(3):251-261.
  4. Mai H, Chen Q, Chen D, et al. Toripalimab or placebo plus chemotherapy as first-line treatment in advanced nasopharyngeal carcinoma: a multicenter randomized phase 3 trial. Nat Med. 2021;27(9):1536-1543.
  5. Yang Y, Qu S, Li J, et al. Camrelizumab versus placebo in combination with gemcitabine and cisplatin as first-line treatment for recurrent or metastatic nasopharyngeal carcinoma (CAPTAIN-1st): a multicentre, randomised, double-blind, phase 3 trial. Lancet Oncol. 2021;22:1162-1174.
  6. Verma A, Burtness B. Top advances of the year: Head and neck cancer. Cancer. 2023;129(9):1308-1312.
  7. Mai H-Q, Chen Q-Y, Chen D-P, et al. Final overall survival analysis of JUPITER-02: A phase 3 study of toripalimab versus placebo in combination with gemcitabine and cisplatin as first-line treatment for recurrent or metastatic nasopharyngeal carcinoma (NPC). Paper presented at: 2023 ASCO Annual Meeting; June 2–6, 2023; Chicago, IL. Abstract 6009.

Disclosure statements are available on the authors' profiles:

Barbara Burtness MD

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